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1.
Nat Prod Res ; : 1-9, 2022 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-36200694

RESUMO

A new biflavone (philonotisflavone-3'''-methyl ether), three diterpenes (lupulin G, lupulin H, lupulin I), a new ecdysteroid (ajugasterone E), and four known compounds were isolated from the whole plant of Ajuga lupulina Maxim. Their structures were determined by spectroscopic analysis, including MS, NMR and ECD spectral data. Compounds 1-3 has DPPH radical scavenging ability, and compound 1 has stronger activity than vitamin C. Compounds 2, 3, 7 and 8 have potential cytotoxic activity against Hela, with IC50 values less than 20.0 µM. Abietane diterpenes 2, 3, 7 and 8 are also found to have NO inhibitory effects with IC50 values less than 40.0 µM.

2.
Nat Prod Res ; 36(21): 5429-5437, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34937440

RESUMO

Four sesquiterpenoids A-D (1-4) were isolated from the ethanol extracts of the leaves and stems from Schisandra chinensis. Their structures and absolute configurations were elucidated by a combination of NMR, MS and ECD. Compounds 1-4 (10 µM) exhibited moderate hepatoprotective activities against APAP-induced LO2 cell damage with increasing cell viability by 18%, 17%, 16%, and 19% compared to the model group (bicyclol, 26%) at 10 µM, respectively. All the compounds displayed no cytotoxic activity against five human cell lines, which also suggested the safety of leaves and stems of S. chinensis as an edible vegetable in a degree.


Assuntos
Lignanas , Schisandra , Sesquiterpenos , Humanos , Schisandra/química , Verduras , Folhas de Planta/química , Sesquiterpenos/análise , Espectroscopia de Ressonância Magnética , Lignanas/química
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